Compound ID | 2810

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Stattic

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. At <25uM concentration it acts as an antivirulence agent (binds to GalU which is involved in lipopolysaccharide core region synthesis), at higher concentrations acts as membrane-active agent
Target Pathogen: Active against Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae
Description: Synthetic compound; known inhibitor of signal transducers and activators of transcription (STAT3); shows synergistic effect with kanamycin, ampicillin, chloramphenicol, gentamicin, and spectinomycin
Institute where first reported: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 211.2
Iso. SMILES: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChI Key: ZRRGOUHITGRLBA-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChI: InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2779853
Citation: https://journals.asm.org/doi/10.1128/aem.01074-23

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