Compound ID | 2811

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8-O-methyltetrangomycin (MTN) and 8-O-methyltetrangulol (MTL)

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; antibiotic resistance determinant Cfr inhibitor (Cfr-dependent activity; inhibits methylation of residue A2503 of 23S rRNA)
Description: Natural product from Streptomyces WAC01849; potentiates PhLOPSa antibiotics (not observed when cfr is absent); speculated to be intermediate product of a kiamycin-like compound
Institute where first reported: Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 336.34
Iso. SMILES: C[C@]1(CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4OC)O
InChI Key: XZLGWJORNHETKI-HXUWFJFHSA-N
Can. SMILES: C[C@]1(CC2=CC=C3C(=C2C(=O)C1)C(=O)C4=CC=CC(=C4C3=O)OC)O
InChI: InChI=1S/C20H16O5/c1-20(24)8-10-6-7-12-17(15(10)13(21)9-20)19(23)11-4-3-5-14(25-2)16(11)18(12)22/h3-7,24H,8-9H2,1-2H3/t20-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/mbio.01791-23

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