Compound ID | 2813

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CU232

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Gram-negatives; inhibits AcrAB-TolC activity
Description: Synthetic compound derived from identified Salmonella enterica serotype Typhimurium efflux pump modulators (EPM35) with increased potency and high selectivity
Institute where first reported: Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 318.34
Iso. SMILES: C1CN(CCC1N)CC(COC2=CC=CC(=C2)C(F)(F)F)O
InChI Key: ADGXNJWEGDDFPZ-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC(=C1)C(F)(F)F)OCC(CN2CCC(CC2)N)O
InChI: InChI=1S/C15H21F3N2O2/c16-15(17,18)11-2-1-3-14(8-11)22-10-13(21)9-20-6-4-12(19)5-7-20/h1-3,8,12-13,21H,4-7,9-10,19H2
External links:
Citation: https://journals.asm.org/doi/10.1128/mbio.02492-23

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