Compound ID | 2814

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CU244

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Gram-negatives; inhibits AcrAB-TolC activity
Description: Synthetic compound derived from identified Salmonella enterica serotype Typhimurium efflux pump modulators (EPM35) with increased potency and high selectivity
Institute where first reported: Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA; Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 333.25
Iso. SMILES: CC[C@H]1[C@@H](CN)[C@@H]1NCC(O)COC2=CC(Cl)=CC(Cl)=C2
InChI Key: FFOPLVSVROOHJT-VXTPIPQJSA-N
Can. SMILES: CC[C@H]1[C@@H](CN)[C@@H]1NCC(COC2=CC(=CC(=C2)Cl)Cl)O
InChI: InChI=1S/C15H22Cl2N2O2/c1-2-13-14(6-18)15(13)19-7-11(20)8-21-12-4-9(16)3-10(17)5-12/h3-5,11,13-15,19-20H,2,6-8,18H2,1H3/t11?,13-,14+,15+/m0/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/mbio.02492-23

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