Compound ID | 282

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A358

Class: Sulfonamide

Agent Type: Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Dehydroquinate synthase inhibitor
Propensity to select resistant mutants: Yes: resistance studies failed to identify mutants not susceptible to A358
Institute where first reported: Arrow Therapeutics
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
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Molecular weight: 590.9
Iso. SMILES: C1=CC(=CC=C1OC(F)(F)F)S(=O)(=O)NC2=C(C=C(C=C2)Cl)NS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F
InChI Key: RIRYPMKEEPIRNS-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)NS(=O)(=O)C2=CC=C(C=C2)OC(F)(F)F)NS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F)Cl
InChI: InChI=1S/C20H13ClF6N2O6S2/c21-12-1-10-17(28-36(30,31)15-6-2-13(3-7-15)34-19(22,23)24)18(11-12)29-37(32,33)16-8-4-14(5-9-16)35-20(25,26)27/h1-11,28-29H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9894770

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