Compound ID | 2823

Update compound information

S-342-3

Class: Antibiofilm agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus; prevents initial adhesion and production of polysaccharide intercellular adhesin required for biofilm formation
Description: Synthetic compound; small molecule with indolylmaleimide core; shows no antibacterial activity but inhibits biofilm formation
Institute where first reported: Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 394.51
Iso. SMILES: O=C1C[C@H](C2=C3N(C(C(C)(C)C)=O)C=C(C)C3=CC=C2)C(=O)N1C4CCCCC4
InChI Key: BLLXFRXSNLSFOY-LJQANCHMSA-N
Can. SMILES: CC1=CN(C2=C1C=CC=C2[C@H]3CC(=O)N(C4CCCCC4)C3=O)C(=O)C(C)(C)C
InChI: InChI=1S/C24H30N2O3/c1-15-14-25(23(29)24(2,3)4)21-17(15)11-8-12-18(21)19-13-20(27)26(22(19)28)16-9-6-5-7-10-16/h8,11-12,14,16,19H,5-7,9-10,13H2,1-4H3/t19-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.01596-23

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