Compound ID | 2829

Update compound information

Shikonin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Membrane-active agent. Induces generation of reactive oxygen species and disrupts integrity of cell membrane when in combination with colistin
Target Pathogen: Active against Staphylococcus aureus and colistin-resistant Escherichia coli (increased susceptibility in synergism with colistin)
Description: Natural product mainly composed of extract from the dried root of Lithospermum erythrorhizon; shows synergistic effect with colistin; reduces colistin MIC to up to 8x in colistin-resistant Escherichia coli,
Institute where first reported: Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, and Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou, Zhejiang, China
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 288.3
Iso. SMILES: CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
InChI Key: NEZONWMXZKDMKF-SNVBAGLBSA-N
Can. SMILES: CC(=CC[C@H](C1=CC(=O)C2=C(C(=CC=C2O)O)C1=O)O)C
InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/479503
Citation: https://journals.asm.org/doi/10.1128/spectrum.01459-23

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.