Compound ID | 2829

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Shikonin

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus and colistin-resistant Escherichia coli (increased susceptibility in synergism with colistin); induces generation of reactive oxygen species and disrupts integrity of cell membrane when in combination with colistin
Description: Natural product mainly composed of extract from the dried root of Lithospermum erythrorhizon; shows synergistic effect with colistin; reduces colistin MIC to up to 8x in colistin-resistant Escherichia coli,
Institute where first reported: Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, and Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou, Zhejiang, China
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 288.3
Iso. SMILES: CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
InChI Key: NEZONWMXZKDMKF-SNVBAGLBSA-N
Can. SMILES: CC(=CC[C@H](C1=CC(=O)C2=C(C(=CC=C2O)O)C1=O)O)C
InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/479503
Citation: https://journals.asm.org/doi/10.1128/spectrum.01459-23

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