AN0128

Class: Borinic acid ester

Spectrum of activity:	Gram-negative
Details of activity:	Was in development as a topical treatment for skin infections, acne and as a toothpaste.No development has been reported and is no longer part of Anacor's pipeline.
Institute where first reported:	Anacor Pharmaceuticals, US; Naeja Pharmaceutical, Inc., Canada
Year first mentioned:	2005
Highest developmental phase:	Phase 2
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CC1=CC=C(C=C1Cl)B(C2=CC=C(C)C(=C2)Cl)OC(=O)C3=NC=CC=C3O
Isomeric SMILES:	B(C1=CC(=C(C=C1)C)Cl)(C2=CC(=C(C=C2)C)Cl)OC(=O)C3=C(C=CC=N3)O
InChI:	InChI=1S/C20H16BCl2NO3/c1-12-5-7-14(10-16(12)22)21(15-8-6-13(2)17(23)11-15)27-20(26)19-18(25)4-3-9-24-19/h3-11,25H,1-2H3
InChI Key:	ZTLSOLUCMQEGEA-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/11704019

External links:
Guide to Pharmacology:	AN0128
Main Source:	https://www.sciencedirect.com/science/article/pii/S0960894X06010456?via%3Dihub