Compound ID | 283

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AN0128

Class: Borinic acid ester

Spectrum of activity: Gram-negative
Details of activity: Was in development as a topical treatment for skin infections, acne and as a toothpaste.No development has been reported and is no longer part of Anacor's pipeline.
Institute where first reported: Anacor Pharmaceuticals, US; Naeja Pharmaceutical, Inc., Canada
Year first mentioned: 2005
Highest developmental phase: Phase 2
Development status: Inactive
Chemical structure(s):
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Molecular weight: 400.06
Iso. SMILES: B(C1=CC(=C(C=C1)C)Cl)(C2=CC(=C(C=C2)C)Cl)OC(=O)C3=C(C=CC=N3)O
InChI Key: ZTLSOLUCMQEGEA-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C=C1Cl)B(C2=CC=C(C)C(=C2)Cl)OC(=O)C3=NC=CC=C3O
InChI: InChI=1S/C20H16BCl2NO3/c1-12-5-7-14(10-16(12)22)21(15-8-6-13(2)17(23)11-15)27-20(26)19-18(25)4-3-9-24-19/h3-11,25H,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11704019
Guide to Pharmacology: AN0128
Citation: https://www.sciencedirect.com/science/article/pii/S0960894X06010456?via%3Dihub

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