Compound ID | 2830

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WQ-3154

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Targets DNA gyrase
Target Pathogen: Active against Salmonella sp.
Description: Synthetic compound; shows similar pharmacophore to WQ-3034 with methyl group at R8 position
Institute where first reported: Wakunaga Pharmaceutical Co., Ltd. (Osaka, Japan); Hokkaido University, International Institute for Zoonosis Control, Sapporo, Japan
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 420.34
Iso. SMILES: CC1=C2C(=CC(=C1N3CC(C3)O)F)C(=O)C(=CN2C4=C(C=C(C(=N4)N)F)F)C(=O)O
InChI Key: QAURAGVLTXYSIZ-UHFFFAOYSA-N
Can. SMILES: CC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3=NC(=C(C=C3F)F)N)F)N4CC(C4)O
InChI: InChI=1S/C19H15F3N4O4/c1-7-14-9(2-11(20)15(7)25-4-8(27)5-25)16(28)10(19(29)30)6-26(14)18-13(22)3-12(21)17(23)24-18/h2-3,6,8,27H,4-5H2,1H3,(H2,23,24)(H,29,30)
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.01330-23

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