Compound ID | 2835

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MMV688508 (Pbc 5)

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Neisseria gonorrhoeae
Description: Compound discovered from the Medicine for Malaria Venture (MMV) Pathogen Box
Institute where first reported: University of Pretoria, Pretoria, South Africa
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 358.36
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CO)F
InChI Key: XBISYWZDDQVGLM-INIZCTEOSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(C=C3)CO)C(=C2)F)C(=O)O1
InChI: InChI=1S/C19H19FN2O4/c1-12(24)21-9-16-10-22(19(25)26-16)15-6-7-17(18(20)8-15)14-4-2-13(11-23)3-5-14/h2-8,16,23H,9-11H2,1H3,(H,21,24)/t16-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/60045898
Citations:
  • https://journals.asm.org/doi/10.1128/aac.00379-17
  • https://www.mmv.org/mmv-open/pathogen-box/about-pathogen-box
  • https://journals.asm.org/doi/10.1128/aac.00348-23

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