Compound ID | 2839

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SMJ-5

Class: Drug efflux pump inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-positive
Mechanism of action: Efflux pump inhibitor. NorA efflux pump inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: Synthetic compound; shows no antibacterial activity alone
Institute where first reported: Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India; Clinical Microbiology and Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 342.39
Iso. SMILES: C/C(/C1=CC(O)=CC(O)=C1)=N\C=2C=CC=CC2C3=CC4=CC=CC=C4N3
InChI Key: OVWPGYQBLFZQPT-OEAKJJBVSA-N
Can. SMILES: C/C(=N\C1=CC=CC=C1C2=CC3=C(C=CC=C3)N2)/C4=CC(=CC(=C4)O)O
InChI: InChI=1S/C22H18N2O2/c1-14(16-10-17(25)13-18(26)11-16)23-21-9-5-3-7-19(21)22-12-15-6-2-4-8-20(15)24-22/h2-13,24-26H,1H3/b23-14+
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.04876-22

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