Compound ID | 2845

Update compound information

KKL-55

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Bacillus anthracis, Shigella flexneri, and Mycobacterium smegmatis; binds to elongation factor thermo-unstable (EF-Tu) inhibiting trans-translation
Description: Synthetic compound; tetrazole-based compound that inhibits trans-translation but not normal translation in protein synthesis
Institute where first reported: Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; Emory Antibiotic Resistance Center (ARC), Emory University, Atlanta, Georgia, USA; Department of Chemistry, Emory University, Atlanta, Georgia, USA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 265.7
Iso. SMILES: CCCN1N=NN=C1NC(=O)C2=CC=CC(Cl)=C2
InChI Key: IBRCUOMIAFDQTM-UHFFFAOYSA-N
Can. SMILES: CCCN1C(=NN=N1)NC(=O)C2=CC=CC(=C2)Cl
InChI: InChI=1S/C11H12ClN5O/c1-2-6-17-11(14-15-16-17)13-10(18)8-4-3-5-9(12)7-8/h3-5,7H,2,6H2,1H3,(H,13,14,16,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/275330991
Citations:
  • https://journals.asm.org/doi/10.1128/aac.01199-17
  • https://www.pnas.org/doi/full/10.1073/pnas.1302816110
  • https://journals.asm.org/doi/10.1128/mbio.01461-23

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.