Compound ID | 2848
RP557
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Acinetobacter baumannii, Enterobacter cloacae, Klebsiella penumoniae, carbapenem-resistant and -susceptible Pseudomonas aeruginosa, methicillin-resistant and -susceptible Staphylococcus aureus, and Staphylococcus epidermidis |
| Description: | Semisynthetic compound derived from cathelicidin LL-37 and cecropin-derived D2A21; shows synergistic effect with carbapenems against carbapenem-resistant Pseudomonas aeruginosa |
| Institute where first reported: | Department of Infectious Disease, Seoul National University, Seoul, Republic of Korea; Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea |
| Year first mentioned: | 2019 |
| Development status: | Experimental |
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