Compound ID | 2849

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Famotidine

Class: Membrane-active agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. Dissipates proton motive force
Target Pathogen: Active against biofilm and planktonic Acinetobacter baumannii
Description: Decreases bacterial load and increases survival rate of mice infected with Acinetobacter baumannii when in combination with rifampicin; repurposed drug (approved for clinical use to inhibit overproduction of gastric acid); shows synergistic effects with rifampicin, ceftriaxone, gentamicin, and polymyxin B; shows intrinsic antimicrobial activity
Institute where first reported: College of Animal Science and Technology, Jilin Agricultural University, Changchun, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.45
Iso. SMILES: C1=C(N=C(S1)N=C(N)N)CSCC/C(=N/S(=O)(=O)N)/N
InChI Key: XUFQPHANEAPEMJ-UHFFFAOYSA-N
Can. SMILES: C(CSCC1=CSC(=N1)N=C(N)N)/C(=N/S(=O)(=O)N)/N
InChI: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5702160
Citation: https://journals.asm.org/doi/10.1128/jb.00187-23

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