Compound ID | 2851

Update compound information

MJ-22

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacterium tuberculosis; cytochrome bc1 inhibitor
Propensity to select resistant mutants: Yes, at 3.33x10^-9 mutation frequency at 5xMIC
Description: Synthetic compound; thiazole; no macrophage cytotoxicity at 200 uM (highest concentration tested)
Institute where first reported: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 349.51
Iso. SMILES: COC1CCC(CCC(C2=C(C)N=C(C3=CC=CS3)S2)=O)CC1
InChI Key: SMFIPKZFWDTWNV-UHFFFAOYSA-N
Can. SMILES: CC1=C(C(=O)CCC2CCC(CC2)OC)SC(=N1)C3=CC=CS3
InChI: InChI=1S/C18H23NO2S2/c1-12-17(23-18(19-12)16-4-3-11-22-16)15(20)10-7-13-5-8-14(21-2)9-6-13/h3-4,11,13-14H,5-10H2,1-2H3
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00251-23

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.