Compound ID | 2852

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B6

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Antimycobacterial
Mechanism of action: Cytochrome bc1 inhibitor
Target Pathogen: Active against Mycobacterium tuberculosis
Propensity to select resistant mutants: Yes, at 2.17x10^-10 mutation frequency at 5xMIC
Description: Synthetic compound; quinoline-amine; macrophage cytotoxicity at high concentration (selectivity index of 79.8)
Institute where first reported: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
Year first mentioned: 2012
Development status: Experimental
Chemical structure(s):
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Molecular weight: 272.41
Iso. SMILES: C1CCC2=C(CC1)SC3=NC4=C(CCCC4)C(=C23)N
InChI Key: VCRYPZHLSGMRQY-UHFFFAOYSA-N
Can. SMILES: C1CCC2=C(CC1)SC3=C2C(=C4CCCCC4=N3)N
InChI: InChI=1S/C16H20N2S/c17-15-10-6-4-5-8-12(10)18-16-14(15)11-7-2-1-3-9-13(11)19-16/h1-9H2,(H2,17,18)
External links:
Citations:
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052951
  • https://journals.asm.org/doi/10.1128/aac.00251-23

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