Compound ID | 2853
Ceftazidime-decorated gold nanoparticles (CAZ_Au NPs)
Class: Membrane-active agent
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against ceftazidime-avibactam-resistant Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae); cell wall synthesis inhibitor additionally membrane-active agent (increases intracellular reactive oxygen species) |
| Description: | Synthetic compound; gold nanoparticle as delivery system; shows 100-90% survival rate for mice with abdominal infection of ceftazidime-resistant Enterobacteriaceae upon treatment |
| Institute where first reported: | Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.00262-23 |
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