Compound ID | 2859

Update compound information

CY-158-11

Class: Antibiofilm agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Inhibits polysaccharide intercellular adhesin (PIA) synthesis
Target Pathogen: Active against Staphylococcus aureus
Description: Synthetic compound; small molecule containing N-maleimide and diphenyl diselenide
Institute where first reported: Wenzhou Medical University, Wenzhou, China; Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 552.17
Iso. SMILES: O=C1C([Se]C2=C(Cl)C=CC=C2)=C([Se]C3=C(Cl)C=CC=C3)C(N1C4=CC=CC=C4)=O
InChI Key: YHUBRHJKSXWSEC-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)N2C(=O)C(=C(C2=O)[Se]C3=C(C=CC=C3)Cl)[Se]C4=C(C=CC=C4)Cl
InChI: InChI=1S/C22H13Cl2NO2Se2/c23-15-10-4-6-12-17(15)28-19-20(29-18-13-7-5-11-16(18)24)22(27)25(21(19)26)14-8-2-1-3-9-14/h1-13H
External links:
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.joc.2c01567
  • https://journals.asm.org/doi/10.1128/spectrum.00045-23

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