Compound ID | 2862
PlyKp104
Class: Bacteriophage and/or bacteriophage-derived product
| Agent Type: | Natural product; Bacteriophage or bacteriphage-derived product; |
| Spectrum of activity: | Gram-negative |
| Target Pathogen: | Active against ESBL- and carbapenemase-producing Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter cloacae, Acinetobacter baumannii, ESBL-producing and susceptible Escherichia coli, Shigella sonnei, and Proteus mirabilis |
| Description: | Natural lysin identified from Klebsiella pneumoniae and Pseudomonas aeruginosa phages; likely not suitable for systemic applications as activity is inhibited in human serum; shows 2-log reduction in bacterial load when applied topically in a Klebsiella pneumoniae mouse skin infection model |
| Institute where first reported: | Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.01519-22 |
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