Compound ID | 2864

Update compound information

Baicalein

Class: Membrane-active agent

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Membrane-active agent. Disrupts integrity of outer and inner cell membrane (membrane-active agent) additionally induces generation of reactive oxygen species; has also been shown to inhibit TetK efflux pump
Target Pathogen: Active against multidrug-resistant Gram-negatives, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus sp.
Description: Natural product from root extract of Scutellaria baicalensis Georgi; shows synergistic effect with doxycycline, cefotaxime, and gentamicin
Institute where first reported: Medical College of Yangzhou University, Yangzhou, China.
Year first mentioned: 2005
Development status: Experimental
Chemical structure(s):
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Molecular weight: 270.24
Iso. SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
InChI Key: FXNFHKRTJBSTCS-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281605
Citations:
  • https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-016-0797-1
  • https://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2005.tb03732.x
  • https://www.sciencedirect.com/science/article/pii/S0003996914001824?via%3Dihub
  • https://journals.asm.org/doi/10.1128/spectrum.04702-22

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