Compound ID | 2867

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Heterocyclic iodonium salt analogue 3a

Synonym(s): Diheterocyclic iodonium derivative 3a  |  heterocyclic diaryliodonium-based inhibitor 3a

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative & Antimycobacterial
Mechanism of action: Targets respiratory proteins dependent on redox cofactors (ex: Glutamate synthase subunit β, betaine aldehyde dehydrogenase, FAD-dependent oxidoreductase, and alkyl hydroperoxide reductase subunit F)
Target Pathogen: Active against carbapenem-resistant Acinetobacter baumannii and Mycobacterium sp.
Description: Synthetic compound derived from diphenyleneiodonium (dpI) chloride; shows synergistic effect with amikacin and tobramycin; shows favourable selectivity index; 0.9 log CFU/ml reduction of A. baumannii in neutropenic thigh infection model
Institute where first reported: Indian Institute of Science Education and Research Pune, Pune, Maharashtra, India
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 321.57
Iso. SMILES: C12=C(SC=C1)[I+]C3=CC=CN=C23.[Cl-]
InChI Key: REHQFORBXCSLAL-UHFFFAOYSA-M
Can. SMILES: C1=CN=C2C3=C([I+]C2=C1)SC=C3.[Cl-]
InChI: InChI=1S/C9H5INS.ClH/c1-2-7-8(11-4-1)6-3-5-12-9(6)10-7;/h1-5H;1H/q+1;/p-1
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.04773-22

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