Compound ID | 2868

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Flufenamic acid

Class: Membrane-active agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Salmonella enterica serovar Typhimurium, methicillin-resistant Staphylococcus aureus and colistin-resistant strains of Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii; disrupts integrity of cell membrane
Description: Synthetic compound; repurposed nonsteroidal anti-inflammatory drug used to treat rheumatic conditions; sensitizer; no inhibitory activity on its own but shows synergistic effect with colistin
Institute where first reported: Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 281.23
Iso. SMILES: C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F
InChI Key: LPEPZBJOKDYZAD-UHFFFAOYSA-N
Can. SMILES: C1=CC(=C(C=C1)NC2=CC(=CC=C2)C(F)(F)F)C(=O)O
InChI: InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.04052-22

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