Compound ID | 287
BMS 181139
Class: Beta-lactam
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Cell wall synthesis inhibitor |
| Target Pathogen: | Active against Escherichia coli, Klebsiella penumoniae, Pseudomonas aeruginosa (including imipenem-resistant strains), and Staphylococcus aureus |
| Description: | A 2-cyanoethylthio carbapenem; substituted with guanidinoethyl moiety at position 1; shows no cross resistance to imipenem-resistant Pseudomonas aeruginosa; Kessler RE, Fung-Tomc J, Minassian B, et al. BMS-181139: In vitro activities in comparison to imipenem and meropenem. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 125. |
| Institute where first reported: | Bristol-Myers Squibb, UK |
| Year first mentioned: | 1994 |
| Development status: | Experimental |
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