Compound ID | 2870

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APC148

Synonym(s): ZN148

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against NDM-producing strains; metallo-beta-lactamase inhibitor
Description: Synthetic compound; zinc-chelator; potentiates meropenem
Institute where first reported: AdjuTec Pharma
Year first mentioned: 2020
Highest developmental phase: Phase 1 (NCT06360640)
Development status: Active as of 2024
Chemical structure(s):
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Molecular weight: 511.57
Iso. SMILES: CN(C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)C(=O)C1=CN=C(C=C1)CN(CC2=CC=CC=N2)CC3=CC=CC=N3
InChI Key: YDMPBIVRJWWDAB-ZYQDXHPFSA-N
Can. SMILES: CN(C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)C(=O)C1=CC=C(CN(CC2=NC=CC=C2)CC3=NC=CC=C3)N=C1
InChI: InChI=1S/C26H33N5O6/c1-30(16-22(33)24(35)25(36)23(34)17-32)26(37)18-8-9-21(29-12-18)15-31(13-19-6-2-4-10-27-19)14-20-7-3-5-11-28-20/h2-12,22-25,32-36H,13-17H2,1H3/t22-,23+,24+,25+/m0/s1
External links:
Guide to Pharmacology: APC148
Citation: https://journals.asm.org/doi/full/10.1128/aac.02415-19?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

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