APC148

Synonym(s): ZN148

Class: Beta-lactamase inhibitor (metallo-beta-lactamase inhibitor)

Spectrum of activity:	Gram-negative
Details of activity:	Active against NDM-producing strains
Description:	Synthetic compound; zinc-chelator; potentiates meropenem
Institute where first reported:	AdjuTec Pharma
Year first mentioned:	2020
Highest developmental phase:	Phase 1 (NCT06360640)
Development status:	Active as of 2024

Chemical structure(s):
Canonical SMILES:	CN(C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)C(=O)C1=CC=C(CN(CC2=NC=CC=C2)CC3=NC=CC=C3)N=C1
Isomeric SMILES:	CN(C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)C(=O)C1=CN=C(C=C1)CN(CC2=CC=CC=N2)CC3=CC=CC=N3
InChI:	InChI=1S/C26H33N5O6/c1-30(16-22(33)24(35)25(36)23(34)17-32)26(37)18-8-9-21(29-12-18)15-31(13-19-6-2-4-10-27-19)14-20-7-3-5-11-28-20/h2-12,22-25,32-36H,13-17H2,1H3/t22-,23+,24+,25+/m0/s1
InChI Key:	YDMPBIVRJWWDAB-ZYQDXHPFSA-N

External links:
Guide to Pharmacology:	APC148
Main Source:	https://journals.asm.org/doi/full/10.1128/aac.02415-19?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org