Compound ID | 2895

Update compound information

Salifungin

Class: Membrane-active agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Membrane-active agent. Disrupts integrity of cell membrane
Target Pathogen: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Listeria monocytogenes, Staphylococcus epidermidis, and Mycobacterium tuberculosis
Description: Synthetic compound identified from TargetMol's approved drug library; reported antifungal activity; cytotoxicity to mammalian cell lines at 16 ug/ml vs MIC at 0.25 ug/ml; no haemolytic activity towards erythrocytes
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 326.57
Iso. SMILES: C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Br)O)Cl
InChI Key: QBSGXIBYUQJHMJ-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)O)C(=O)NC2=CC=C(C=C2)Cl)Br
InChI: InChI=1S/C13H9BrClNO2/c14-8-1-6-12(17)11(7-8)13(18)16-10-4-2-9(15)3-5-10/h1-7,17H,(H,16,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/77254
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00611

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.