Compound ID | 2895

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Salifungin

Class: Membrane-active agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Listeria monocytogenes, Staphylococcus epidermidis, and Mycobacterium tuberculosis; disrupts integrity of cell membrane
Description: Synthetic compound identified from TargetMol's approved drug library; reported antifungal activity; cytotoxicity to mammalian cell lines at 16 ug/ml vs MIC at 0.25 ug/ml; no haemolytic activity towards erythrocytes
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 326.57
Iso. SMILES: C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Br)O)Cl
InChI Key: QBSGXIBYUQJHMJ-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)O)C(=O)NC2=CC=C(C=C2)Cl)Br
InChI: InChI=1S/C13H9BrClNO2/c14-8-1-6-12(17)11(7-8)13(18)16-10-4-2-9(15)3-5-10/h1-7,17H,(H,16,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/77254
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00611

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