Compound ID | 2897

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Meropenem/ANT3310

Class: Beta-lactam + beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against carbapenem-resistant Gram-negatives; ANT3310 inhibits serine beta-lactamases (OXA carbapenemase)
Combined with other compounds: Yes
Description: Developed for hospital acquired infections (complicated urinary tract infection, bacterial pneumoniae, ventilator-associated bacterial pneumoniae, and intra-abdominal infection)
Institute where first reported: Antabio SAS, Labège, France
Year first mentioned: 2024
Highest developmental phase: Phase 1 (NCT05905913)
Development status: Active as of 2024
Chemical structure(s):
ANT3310
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Molecular weight: 262.19
Iso. SMILES: C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)[O-])F.[Na+]
InChI Key: UIJIKXQAJBMNIR-JBUOLDKXSA-M
Can. SMILES: C1C[C@@H](F)N2C[C@@H]1N(C2=O)OS(=O)(=O)[O-].[Na+]
InChI: InChI=1S/C6H9FN2O5S.Na/c7-5-2-1-4-3-8(5)6(10)9(4)14-15(11,12)13;/h4-5H,1-3H2,(H,11,12,13);/q;+1/p-1/t4-,5+;/m1./s1
Meropenem
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Molecular weight: 383.46
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O
InChI Key: DMJNNHOOLUXYBV-PQTSNVLCSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@@H](C(=O)N(C)C)NC3)C(=O)O
InChI: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/153516440
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/441130
Citation: https://journals.asm.org/doi/10.1128/aac.01120-23

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