Compound ID | 2898

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Mavintramycin A

Class: Protein synthesis inhibitor

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Mycobacterium avium and Mycobacterium intracellulare
Description: Natural product from Streptomyces sp. OPMA40551; no cytotoxicity towards THP-1 macrophages; shows additive effect with rifampicin and clarithromycin against Mycobacterium avium
Institute where first reported: Drug Discovery Laboratory, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 480.56
Iso. SMILES: CN(C)[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@H]2CC[C@H](N3C=CC(NC(/C=C(\C)/C)=O)=NC3=O)O[C@@H]2C)O[C@@H]1C
InChI Key: RANKAOMWUWJVAD-DEBTXEAPSA-N
Can. SMILES: C/C(=C\C(=O)NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H]([C@@H](C)O2)O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](C)O3)N(C)C)O)O)/C
InChI: InChI=1S/C23H36N4O7/c1-12(2)11-17(28)24-16-9-10-27(23(31)25-16)18-8-7-15(13(3)32-18)34-22-21(30)20(29)19(26(5)6)14(4)33-22/h9-11,13-15,18-22,29-30H,7-8H2,1-6H3,(H,24,25,28,31)/t13-,14-,15+,18-,19-,20+,21-,22-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00917-23

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