Cresomycin

Class: Protein synthesis inhibitor

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against susceptible and multidrug-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus haemolyticus, Streptococcus pneumoniae, Streptococcus pyogenes, multidrug-resistant Enterococcus faecalis, multidrug- and vancomycin-resistant Enterococcus faecium, Clostridioides difficile, Neisseria gonorrhoeae, susceptible and multidrug-resistant Escherichia coli, carbapenem-resistant: Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa; binds to ribosomes
Description:	Synthetic compound; 100% survival of mice infected with cfr-expressing Staphylococcus aureus after subcutaneous treatment with cresomycin vs 10% survival without treatment
Year first mentioned:	2024
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC(C)C[C@@H]1CCO[C@@H]2[C@@H](C1)CN[C@@H]2C(=O)N[C@@H]3[C@H](C)/C=C\CCS[C@@H]4[C@@H]([C@H]([C@H]([C@@H]3O4)O)O)O
Isomeric SMILES:	C[C@@H]1/C=C\CCS[C@@H]2[C@@H]([C@H]([C@H]([C@@H]([C@@H]1NC(=O)[C@@H]3[C@H]4[C@@H](C[C@@H](CCO4)CC(C)C)CN3)O2)O)O)O
InChI:	InChI=1S/C25H42N2O6S/c1-13(2)10-15-7-8-32-22-16(11-15)12-26-18(22)24(31)27-17-14(3)6-4-5-9-34-25-21(30)19(28)20(29)23(17)33-25/h4,6,13-23,25-26,28-30H,5,7-12H2,1-3H3,(H,27,31)/b6-4-/t14-,15+,16+,17-,18+,19+,20-,21-,22-,23-,25-/m1/s1
InChI Key:	GMONVEGLHZWYNO-JBYNEVPESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/169247206

External links:
Guide to Pharmacology:	cresomycin
Main Source:	https://www.science.org/doi/10.1126/science.adk8013