Compound ID | 290

Update compound information

CL 191121

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Similar activity against Enterobacteriaceae, B. fragilis and MSSA as imipenem
Description: 1. Weiss WJ, Yang Y, Petersen PJ, et al. In vitro antibacterial activity and β-lactamase stability of novel THF carbapenems. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 128. 2. Weiss WJ, Petersen PJ, Jacobus NV, et al. In vivo therapeutic efficacy of novel tetrahydrofuranyl carbapenems. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 128.
Institute where first reported: Lederle Laboratories, USA
Year first mentioned: 1994
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
Click here for structure editor
Molecular weight: 342.41
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@@H]3CCO[C@@H]3CN)C(=O)O)[C@@H](C)O
InChI Key: HTXPDRHSGPNWKA-VRGHXPGPSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@@H]3CCO[C@@H]3CN)C(=O)O
InChI: InChI=1S/C15H22N2O5S/c1-6-11-10(7(2)18)14(19)17(11)12(15(20)21)13(6)23-9-3-4-22-8(9)5-16/h6-11,18H,3-5,16H2,1-2H3,(H,20,21)/t6-,7-,8-,9-,10-,11-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9906050
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89143/pdf/ac000454.pdf
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89143/pdf/ac000454.pdf

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.