Compound ID | 2909

Update compound information

NSC 33353

Synonym(s): NSC-33353  |  NSC33353

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli, Acinetobacter baumannii, Enterobacter cloacae, and Klebsiella pneumoniae with novobiocin and erythromycin; efflux pump AcrA inhibitor
Description: Compound from the National Cancer Institute (NCI) compound library; potentiates novobiocin and erythromycin activity in Gram-negatives; shows no antibacterial effect alone
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.8
Iso. SMILES: CC1=CC(=C2C=C(C=CC2=N1)NC(=O)/C=C\C3=CC=CC=C3Cl)N
InChI Key: MLKVGBZASWPPOU-TWGQIWQCSA-N
Can. SMILES: CC1=CC(=C2C=C(C=CC2=N1)NC(=O)/C=C\C3=C(C=CC=C3)Cl)N
InChI: InChI=1S/C19H16ClN3O/c1-12-10-17(21)15-11-14(7-8-18(15)22-12)23-19(24)9-6-13-4-2-3-5-16(13)20/h2-11H,1H3,(H2,21,22)(H,23,24)/b9-6-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/40492789
Citation: https://pubs.acs.org/doi/full/10.1021/acsinfecdis.6b00167

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