Compound ID | 291

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DU 6681

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, and Haemophilus influenzae
Description: Parent compound of DZ-2640; Hohmura M, Tanaka M, Ishida H, et al. DZ-2640, a new Cephalosporin antibiotic, 2: In vitro antimicrobial activity and β-lactamase stability of DU-6681, a parent compound of DZ-2640. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 136.
Institute where first reported: Daiichi Pharmaceutical Co. Ltd., Japan
Year first mentioned: 1995
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 349.41
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3CC4=NC=CN4C3)C(=O)O)[C@@H](C)O
InChI Key: SYFIHQJVKJGGGB-SXLYUPOASA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3CC4=NC=CN4C3)C(=O)O
InChI: InChI=1S/C16H19N3O4S/c1-7-12-11(8(2)20)15(21)19(12)13(16(22)23)14(7)24-9-5-10-17-3-4-18(10)6-9/h3-4,7-9,11-12,20H,5-6H2,1-2H3,(H,22,23)/t7-,8-,9+,11-,12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9819755
Citation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163897/pdf/411260.pdf

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