Compound ID | 2910

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NSC 305798

Synonym(s): NSC-305798  |  NSC305798

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Gram-negatives; efflux pump AcrA inhibitor
Description: Compound from the National Cancer Institute (NCI) compound library; potentiates erythromycin (and to a lesser extent, novobiocin) activity in Gram-negatives; reported to have anti-malarial activity; shows antinbacterial activity at 50 uM
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 404.35
Iso. SMILES: C1CCNC(C1)C(C2=CC(=NC(=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F)O
InChI Key: OCVRKDMRZFCUEE-UHFFFAOYSA-N
Can. SMILES: C1CCNC(C1)C(C2=CC(=NC(=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F)O
InChI: InChI=1S/C19H18F6N2O/c20-18(21,22)13-6-4-11(5-7-13)15-9-12(10-16(27-15)19(23,24)25)17(28)14-3-1-2-8-26-14/h4-7,9-10,14,17,26,28H,1-3,8H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/328144
Citation: https://pubs.acs.org/doi/full/10.1021/acsinfecdis.6b00167

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