Compound ID | 2911

Update compound information

BDM91288

Class: Drug efflux pump inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Efflux pump inhibitor. AcrB inhibitor
Target Pathogen: Active against Klebsiella pneumoniae with levofloxacin including against AcrAB-TolC overexpression strains (RamR mutants)
Description: Synthetic compound; pyridylpiperazine-based compound; combination with levofloxacin improves Klebsiella pneumoniae clearance in mouse than levofloxacin alone
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 331.84
Iso. SMILES: C1CN(CCN1)C2=CC3=CC(=C(N=C3C=C2)N4CCNCC4)Cl
InChI Key: WOZFYSNOHHYUAU-UHFFFAOYSA-N
Can. SMILES: C1=CC2=NC(=C(C=C2C=C1N3CCNCC3)Cl)N4CCNCC4
InChI: InChI=1S/C17H22ClN5/c18-15-12-13-11-14(22-7-3-19-4-8-22)1-2-16(13)21-17(15)23-9-5-20-6-10-23/h1-2,11-12,19-20H,3-10H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/166485295
Citation: https://www.embopress.org/doi/full/10.1038/s44321-023-00007-9

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