Compound ID | 2912

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BDM91270

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli with antibiotic; efflux pump AcrB inhibitor
Description: Synthetic compound; has a pyridylpiperazine core; boosts activity of chloramphenicol, oxacillin, piperacillin, fusidic acid, novobiocin, linezolid, erythromycin, and ciprofloxacin; shows no antibacterial activity alone
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 419.73
Iso. SMILES: C1CN(CCN1)C2=C(C=C(C=N2)C(=O)OC3=CC=CC(=C3)CN)Cl.Cl.Cl
InChI Key: GKQBSWGNHZXAHN-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC(=C1)CN)OC(=O)C2=CN=C(C(=C2)Cl)N3CCNCC3.Cl.Cl
InChI: InChI=1S/C17H19ClN4O2.2ClH/c18-15-9-13(11-21-16(15)22-6-4-20-5-7-22)17(23)24-14-3-1-2-12(8-14)10-19;;/h1-3,8-9,11,20H,4-7,10,19H2;2*1H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/168476154
Citation: https://www.sciencedirect.com/science/article/pii/S0223523423005962?via%3Dihub

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