Pyridomycin

Class: InhA inhibitor

Details of activity:	Active against Mycobacterium tuberculosis; competitive inhibitor of NADH in InhA (an essential fatty acid synthesis enzyme)
Description:	Natural product from Streptomyces pyridomyceticus (also from Dactylosporangium fulvum); has activity against Mycobacteria tuberculosis in macrophages
Year first mentioned:	2012
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC/C(=C\1/C(=O)O[C@H](C)[C@@H](C(=O)N[C@@H](CC2=CC=CN=C2)[C@H]([C@@H](C)C(=O)O1)O)NC(=O)C3=NC=CC=C3O)/C
Isomeric SMILES:	CC/C(=C\1/C(=O)O[C@@H]([C@@H](C(=O)N[C@H]([C@H]([C@H](C(=O)O1)C)O)CC2=CN=CC=C2)NC(=O)C3=C(C=CC=N3)O)C)/C
InChI:	InChI=1S/C27H32N4O8/c1-5-14(2)23-27(37)38-16(4)20(31-25(35)21-19(32)9-7-11-29-21)24(34)30-18(12-17-8-6-10-28-13-17)22(33)15(3)26(36)39-23/h6-11,13,15-16,18,20,22,32-33H,5,12H2,1-4H3,(H,30,34)(H,31,35)/b23-14-/t15-,16-,18+,20+,22+/m1/s1
InChI Key:	WHIKSLGSXKIHCA-IGCCMALHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/3037036

External links:
Guide to Pharmacology:	pyridomycin
Main Source:	https://www.embopress.org/doi/full/10.1002/emmm.201201689