Compound ID | 2915

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Lusutrombopag

Class: Membrane-active agent

Spectrum of activity: Gram-positive
Details of activity: Active against vancomycin-resistant Enterococcus sp.; dissipates membrane potential
Description: Synthetic compound; approved by FDA as a thrombopoietin receptor agonist; a repurposed drug; shows synergistic effect with aminoglycosides; no haemolytic activity observed; shows human cell line toxicity at 10xMIC; reduces bacterial load with tobramycin in murine peritonitis infection model with vancomycin-resistant Enterococcus
Institute where first reported: Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha 410005, China
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 591.55
Iso. SMILES: CCCCCCO[C@@H](C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(C(=C3)Cl)/C=C(\C)/C(=O)O)Cl
InChI Key: NOZIJMHMKORZBA-KJCUYJGMSA-N
Can. SMILES: CCCCCCO[C@@H](C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(/C=C(\C)/C(=O)O)C(=C3)Cl)Cl
InChI: InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/49843517
Guide to Pharmacology: lusutrombopag
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00737

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