Compound ID | 2916
Silver N-heterocyclic carbene halido complex
Class: Small molecule antibacterial agent
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against Escherichia coli, Pseudomonas aeruginosa, Klebsiella penumoniae, and Acinetobacter baumannii; binds to thioredoxin and glutathione reductases in E. coli |
| Description: | Synthetic compound; no cytotoxicity to Caco-2 cells at 100 uM (highest concentration tested vs MIC at ≤20 uM); a metallo organic compound (metal organic framework) |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00104 |
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