Compound ID | 2917
Oct-TriA5 (tridecaptin A5 derivative)
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa; membrane-active agent (only for Gram-positives) |
| Description: | Semisynthetic compound; analogue of natural product tridecaptin A5 discovered form genome mining of Paenibacillus sp. JJ-21 with the compound's lipid tail replaced with octanoyl chain; derivative Oct-His9 shows reduced HepG2 cytotoxicity and low haemolysis (~>18x less toxic) vs precursor compound |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acschembio.4c00034 |
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