Compound ID | 2924

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Compound III13 (2-phenyl-1H-phenanthro[9,10-d]imidazole-antimicrobial peptide (AMP) mimic conjugate III13)

Class: Membrane-active agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; disrupts integrity of cell membrane
Description: Synthetic compound; antimicrobial peptide mimic; no cytotoxicity observed to human cell line LO2 at 16 ug/ml (vs MIC at 0.5-2 ug/ml); higher survival rate at 5mg/kg dose in mice (0.4-2.15%) infected with MRSA than seen for vancomycin
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 644.69
Iso. SMILES: CN(C)C=1C=CC(=CC1)C2=NC3=C(N2CCCC[N+](C)(CC(NCCCCC)=O)C)C4=C(C=CC=C4)C5=C3C=CC=C5.[Br-]
InChI Key: NWZCTQSVCIUCEZ-UHFFFAOYSA-N
Can. SMILES: CCCCCNC(=O)C[N+](C)(C)CCCCN1C2=C3C=CC=CC3=C4C=CC=CC4=C2N=C1C5=CC=C(C=C5)N(C)C.[Br-]
InChI: InChI=1S/C36H45N5O.BrH/c1-6-7-12-23-37-33(42)26-41(4,5)25-14-13-24-40-35-32-18-11-9-16-30(32)29-15-8-10-17-31(29)34(35)38-36(40)27-19-21-28(22-20-27)39(2)3;/h8-11,15-22H,6-7,12-14,23-26H2,1-5H3;1H
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00436

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