Compound ID | 2926

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SG-B-52

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; disrupts integrity of cell membrane (membrane-active agent) when in combination with ampicillin or amoxicillin
Description: Synthetic compound; weakly inhibits MRSA on its own (220-240 uM); potentiates amoxicillin and ampicillin (reduces MIC to 8.8 fold); low haemolytic activity (16% lysis at 100 uM) and mammalian cytotoxicity; prevents formation of biofilm and disrupts established biofilm; shows better therapeutic outcome of MRSA infection in rats compared to vancomycin when administered in combination with amoxicillin and ampicillin
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 510.82
Iso. SMILES: O=C(NCC[NH3+])C1=CC=C2N=C(CCCCCCCCCCC)C(CCCCCCCCCC)=CC2=C1
InChI Key: LKBOVXJUZNPOGY-UHFFFAOYSA-O
Can. SMILES: CCCCCCCCCCCC1=C(CCCCCCCCCC)C=C2C=C(C=CC2=N1)C(=O)NCC[NH3+]
InChI: InChI=1S/C33H55N3O/c1-3-5-7-9-11-13-15-17-19-21-31-28(20-18-16-14-12-10-8-6-4-2)26-30-27-29(22-23-32(30)36-31)33(37)35-25-24-34/h22-23,26-27H,3-21,24-25,34H2,1-2H3,(H,35,37)/p+1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00696

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