Compound ID | 2927

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SG-B-22

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; disrupts integrity of cell membrane (membrane-active agent) when in combination with ampicillin or amoxicillin
Description: Synthetic compound; weakly inhibits MRSA on its own (220-240 uM); potentiates amoxicillin and ampicillin (reduces MIC to 4.8 fold); low haemolytic activity (34.1% lysis at 100 uM) and mammalian cytotoxicity
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 398.61
Iso. SMILES: O=C(NCC[NH3+])C1=CC=C2N=C(CCCCCCC)C(CCCCCC)=CC2=C1
InChI Key: GQZBXXKTXMWXLL-UHFFFAOYSA-O
Can. SMILES: CCCCCCCC1=C(CCCCCC)C=C2C=C(C=CC2=N1)C(=O)NCC[NH3+]
InChI: InChI=1S/C25H39N3O/c1-3-5-7-9-11-13-23-20(12-10-8-6-4-2)18-22-19-21(14-15-24(22)28-23)25(29)27-17-16-26/h14-15,18-19H,3-13,16-17,26H2,1-2H3,(H,27,29)/p+1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00696

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