Compound ID | 2928

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BGAz 002 (azetidine derivative)

Class: Mycolic acid synthesis inhibitor

Details of activity: Active against susceptible and multidrug-resistant Mycobacterium tuberculosis
Description: Synthetic compound; analogues with activity reported (BGAz-002 to BGAz-005)
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 474.44
Iso. SMILES: FC(OC1=CC=C([C@@H]2N(CC3=C(OC(F)(F)F)C=CC=C3)[C@H](CN4CCCC4)C2)C=C1)(F)F
InChI Key: PDWZVLVPQFNLNB-AZUAARDMSA-N
Can. SMILES: C1=CC(=C(C=C1)OC(F)(F)F)CN2[C@@H](C[C@@H]2C3=CC=C(C=C3)OC(F)(F)F)CN4CCCC4
InChI: InChI=1S/C23H24F6N2O2/c24-22(25,26)32-19-9-7-16(8-10-19)20-13-18(15-30-11-3-4-12-30)31(20)14-17-5-1-2-6-21(17)33-23(27,28)29/h1-2,5-10,18,20H,3-4,11-15H2/t18-,20+/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01643
Patent: WO2020206594A1

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