Compound ID | 2929
Neomycin-X8 combination
Class: Small molecule antibacterial agent
| Agent Type: | Semisynthetic; Small molecule; Direct acting; Antibiotic adjuvant; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Binds to lipopolysaccharide enhancing membrane permeability |
| Target Pathogen: | Active against Escherichia coli and Pseudomonas aeruginosa when combined with neomycin |
| Description: | Semisynthetic compound; X8 is a p-dimethylamino pyridine-derivative of xanthone; potentiates neomycin (4-fold reduction in MIC); reduces bacterial load (E.coli, P. aeruginosa, or mixed infection) by 2.5~3.5 log CFU in murine wound infection when in combination with neomycin; shows no antibacterial activity alone |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00471 |
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