Compound ID | 293

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DX-8739

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Combined with other compounds: In preclinical trials was coadministered with cilastatin
Description: A dehydropeptidase I stable carbapenem; shows good safety profile
Institute where first reported: Daiichi Sankyo Pharmaceutical, Japan
Year first mentioned: 1992
Development status: Experimental
Chemical structure(s):
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Molecular weight: 539.65
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N4CCN(CC4)C(=O)[C@H](CCCN)O)C(=O)O)[C@@H](C)O
InChI Key: OFSRPSJCLWGQAZ-KHQOANHYSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@@H](C(=O)N4CCN(CC4)C(=O)[C@H](CCCN)O)NC3)C(=O)O
InChI: InChI=1S/C24H37N5O7S/c1-12-18-17(13(2)30)23(34)29(18)19(24(35)36)20(12)37-14-10-15(26-11-14)21(32)27-6-8-28(9-7-27)22(33)16(31)4-3-5-25/h12-18,26,30-31H,3-11,25H2,1-2H3,(H,35,36)/t12-,13-,14+,15+,16+,17-,18-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9871971
Citation: https://academic.oup.com/jac/article/38/2/287/794897/In-vitro-interactions-of-DX-8739-a-new-carbapenem

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