Compound ID | 2933

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JSF-3269 (benzothiophene derivative)

Class: Nitrofuran

Spectrum of activity: Gram-positive
Details of activity: Active against Enterococcus faecium
Description: Synthetic compound; derived from hit JSF-2827 with improved pharmacokinetic profile and mouse liver microsome half-life; no cytotoxicity to Vero cells at >120 uM; similar efficacy to vancomycin (and inferior to linezolid) in acute peritonitis–sepsis infection by vancomycin-resistant Enterococcus faecium in mouse
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 400.19
Iso. SMILES: O=C(C1=CC=C([N+]([O-])=O)O1)NNC(C2=C(Cl)C3=CC=C(Cl)C=C3S2)=O
InChI Key: PHMVXRKNBOTKIH-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1Cl)SC(=C2Cl)C(=O)NNC(=O)C3=CC=C([N+](=O)[O-])O3
InChI: InChI=1S/C14H7Cl2N3O5S/c15-6-1-2-7-9(5-6)25-12(11(7)16)14(21)18-17-13(20)8-3-4-10(24-8)19(22)23/h1-5H,(H,17,20)(H,18,21)
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01846

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