Compound ID | 2936
CGS20 (RRRLARRLIFFIRRAW-NH2)
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active against methicillin-resistant Staphylococcus aureus; disrupts integrity of cell membrane (membrane-active agent) and additionally targets folate biosynthesis |
| Description: | Semisynthetic compound; derived from sea cucumber haemolytic lectin; no haemolytic activity and cytotoxicity to HEK293 cells at 320 uM (vs MIC at 3 uM); reduces MRSA load to 5.9 log CFU in mouse cutaneous infection model |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01360 |
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