Compound ID | 2938

Update compound information

ML346

Synonym(s): ML-346  |  ML 346

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Sortase inhibitor
Target Pathogen: Active against Streptococcus pyogenes and Staphylococcus aureus sortase
Description: Synthetic compound; previously reported as an activator of heat shock protein Hsp70; reduces pathogenicity and virulence of Staphylococcus aureus in Galleria mellonella
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 272.26
Iso. SMILES: COC1=CC=C(C=C1)/C=C/C=C2C(=O)NC(=O)NC2=O
InChI Key: IXYLVJHFJKDHRM-NSCUHMNNSA-N
Can. SMILES: COC1=CC=C(/C=C/C=C2C(=O)NC(=O)NC2=O)C=C1
InChI: InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H,1H3,(H2,15,16,17,18,19)/b3-2+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/767276
Citation: https://pubs.rsc.org/en/content/articlelanding/2022/md/d1md00316j

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