Compound ID | 2939

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BDM88855

Class: Drug efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli; efflux pump AcrB inhibitor
Description: Synthetic compound; reduces MIC of several antibiotics (ex: oxacillin, pyridomycin, linezolid, novobiocin, fusidic acid, chloramphenicol); no intrinsic antibacterial activity
Institute where first reported: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, U1019—UMR 9017—CIIL—Center for Infection and Immunity of Lille, F-59000 Lille, France
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 247.72
Iso. SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3C=C2Cl
InChI Key: JJZVQFQJCHXCFQ-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1)N=C(C(=C2)Cl)N3CCNCC3
InChI: InChI=1S/C13H14ClN3/c14-11-9-10-3-1-2-4-12(10)16-13(11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/153987774
Citation: https://www.nature.com/articles/s41467-021-27726-2

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