Compound ID | 294

Update compound information

FR 21818

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Antibacterial activity of FR21818 is similar to that of biapenem against S. aureus, E. faecalis, E. coli, K. pneumoniae, H. influenzae and P. aeruginosa. After injection in monkeys, the maintainence in the blood plasma is longer compared to biapenem. Injection into rats with for 2 weeks showed no severe side effects.
Description: Tawara S, Matsumoto S, Matsumoto Y, et al. FR21818, a new parenteral carbapenem: preclinical evaluation of (2) in vivo antibacterial activity, pharmacokinetics and toxicity. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 138.
Institute where first reported: Fujisawa Pharm. Co., Japan
Year first mentioned: 1995
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
Click here for structure editor
Molecular weight: 487.01
Iso. SMILES: CC1[C@H]2[C@H](C(=O)N2C(=C1SC3CC(NC3)CC4=CC=[N+](N4C)C(C)O)C(=O)O)C(C)O.[Cl-]
InChI Key: QMYUMIVUHQXKRQ-QGZCDWIBSA-N
Can. SMILES: CC1[C@H]2[C@@H](C(C)O)C(=O)N2C(=C1SC3CC(CC4=CC=[N+](C(C)O)N4C)NC3)C(=O)O.[Cl-]
InChI: InChI=1S/C21H30N4O5S.ClH/c1-10-17-16(11(2)26)20(28)25(17)18(21(29)30)19(10)31-15-8-13(22-9-15)7-14-5-6-24(12(3)27)23(14)4;/h5-6,10-13,15-17,22,26-27H,7-9H2,1-4H3;1H/t10?,11?,12?,13?,15?,16-,17+;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/134692314
Citation: https://reader.elsevier.com/reader/sd/pii/0960894X9500380C?token=8E92E5DC46C392AB72196E1D6404FE25D6E88697743DA693F50D64C873C80AA874BA9ED882576EE93A28DE833B42D783

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.