Compound ID | 2946

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Antibiotic 1717

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, vancomycin intermediate Staphylococcus aureus, Enterococcus faecalis, vancomycin-resistant and -susceptible Enterococcus faecium, Staphylococcus epidermidis, and Streptococcus pyogenes; aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor)
Description: Synthetic compound
Institute where first reported: Department of Medicine, University of Washington, Seattle, Washington, USA
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 409.29
Iso. SMILES: ClC1=CC(Cl)=C2NCC[C@@H](NCCCNC3=NC=4C=CC(F)=NC4N3)C2=C1
InChI Key: FPNBGOOGFIKSDR-CYBMUJFWSA-N
Can. SMILES: C(CN[C@@H]1CCNC2=C(C=C(C=C12)Cl)Cl)CNC3=NC4=C(N=C(C=C4)F)N3
InChI: InChI=1S/C18H19Cl2FN6/c19-10-8-11-13(4-7-23-16(11)12(20)9-10)22-5-1-6-24-18-25-14-2-3-15(21)26-17(14)27-18/h2-3,8-9,13,22-23H,1,4-7H2,(H2,24,25,26,27)/t13-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00999-17

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